TOXICOLOGY AND APPLIED PHARMACOLOGY 17,337-343(1970) Convulsions Induced by 2-N-Di-n-Butyiaminoethanoll
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Convulsions Induced by 2-N-Di-n-Butylaminoethanol. HARTUNG, ROLF, PITTLE, LESTER B., and CORNISH, HERBERT, H. (1970). Toxicol. Appl. Pharmacol. 17, 337-343. Dibutylaminoethanol (Bu,AE) produces convulsions in rats leading to respiratory arrest regardless of route of administration. The lethality of 5 x LD50 doses of BuzAE can be readily overcome by artificial respiration for 2-4 hr. In vivo phrenic nerve-diaphragm preparations indicate that the respiratory arrest is due to a neuromuscular blockade. Spontaneous activity of the phrenic nerve increases during convulsions and persists during blockade. Pretreatment with mephenesin or diphenylhydantoin, but not pentobarbital, was effective in counteracting convulsions and respiratory arrest. BuzAE has also been shown to be a moderate inhibitor of acetylcholinesterase. It is proposed that the increased nerve activity during convulsions with its simultaneous increase in acetylcholine release, acts in concert with the moderate level of cholinesterase inhibition, producing a neuromuscular blockade due to excessive acetylcholine accumulation at the junction.
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تاریخ انتشار 2003